News

News

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            [slug] => Reunion-after-31-years-GENTIS-proudly-accompanies-Arthur-Chareire-and-his-biological-mother
            [title] => Reunion after 31 Years: GENTIS  proudly accompanies Arthur Chareire and his biological mother
            [description] => One afternoon in September, at the GENTIS testing center, the atmosphere suddenly became warmly emotional. It was the moment when Arthur Chareire, a young man with French nationality, was reunited with his biological mother – Mrs. Nguyễn Thị Hợi – after 31 years apart. What seemed like a story straight out of a movie happened in real life, stirring deep emotions among those present.
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The story began about four months ago, when Arthur contacted Dân trí newspaper to share his wish to find his biological mother in Vietnam – someone he had never seen since he was a child. Arthur revealed that he had always felt a part of his life was missing, and the burning desire to know his roots had never faded.

The journey of connection started from a news article

After Dân trí published an article about Arthur’s search for his mother, the information quickly spread throughout the community. Among many readers, a woman named Nguyễn Thị Hợi quietly came to the newsroom. After reading the article, she felt the details matched the child she had once given birth to.

Wanting to confirm their relationship, the family requested DNA testing to clarify their biological connection. With support and coordination from Dân trí, GENTIS sponsored and covered all costs for the voluntary DNA testing for the family.

GENTIS – A strong bridge between science and emotion

In May 2025, Arthur’s hair and nail samples were sent from France, and Mrs. Hợi’s blood sample was collected and analyzed at GENTIS. After a rigorous examination process, the test results accurately confirmed the mother-child biological relationship between the two.

This result was not just a scientific conclusion but also the key that opened the door to reunion after 31 years of separation. It was a moment full of emotion for everyone—from the family, the GENTIS team, to the Dân trí journalists.

Returning to roots – The journey concludes with love

After receiving the voluntary DNA test results, Arthur prepared all necessary procedures to return to Vietnam. On September 19, he arrived at the GENTIS center with his mother to conduct official administrative DNA testing, the final step to complete his citizenship paperwork in Vietnam.

Throughout this process, Arthur’s family received support not only from GENTIS but also from Colonel Hà Quốc Khanh, who accompanied, assisted, and helped diligently and effectively. The family expressed deep gratitude to all individuals and organizations that helped make Arthur’s journey back to his roots smooth and full of love.

GENTIS – Accompanying journeys to find one’s origins

This special event once again affirmed the humanitarian role of DNA testing technology, which not only serves scientific purposes but also becomes an emotional bridge connecting families and healing past wounds.

With over 15 years of experience, GENTIS continuously strives to provide accurate, secure, and dedicated testing services, serving thousands of families on their journeys to find relatives, verify biological relationships, or complete legal procedures.

In the case of Arthur and Mrs. Hợi, GENTIS was not just the place for testing but also a witness to a tearful and joyful reunion after 31 years of waiting.

Connecting communities through true values

Beyond providing services, GENTIS aims to spread profound humanitarian values to the community. Arthur’s story is a clear example that when science is used correctly and timely, it can become a miraculous tool to connect people, heal, and open new hopes.

GENTIS is honored to accompany, witness, and share this great joy with Arthur’s family. It is a pride not only in professional expertise but also in the mission to spread love, unity, and the core values of family.

Arthur Chareire’s journey was not simply about finding his biological mother but also about finding himself, his roots, memories, and lost connections. And through this journey, it shows that no matter how much time passes, a mother’s love never fades—just a glimmer of hope, an opened door, and miracles can happen.

GENTIS will continue to be the place that empowers journeys to reunite families, serving as a bridge between science and emotion, between present and past, between separation and reunion.

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In the context of continuous advancement in modern medicine, the intersection of genetic technology, artificial intelligence (AI), and assisted reproductive medicine is opening new pathways, bringing hope to millions of infertile couples in Vietnam.

To update the latest knowledge, connect leading experts, and expand collaboration opportunities, the specialized workshop: "Updating Knowledge on Genetic Applications and AI Trends in Assisted Reproduction" will officially take place on the afternoon of Saturday, October 11, 2025, in Hanoi.
The event is expected to gather hundreds of experts, doctors, researchers, and representatives from medical facilities nationwide to attend and engage in professional exchanges.

Workshop Chairs:

  • Prof. Dr. Nguyen Dinh Tao – President of Hanoi Assisted Reproduction Association

  • Assoc. Prof. Dr. Tran Duc Phan – President of Vietnam Medical Genetics Association

  • Dr. Nguyen Quang Vinh – Director of GENTIS Testing Center

Presentation Program:

  • Assoc. Prof. Dr. Trinh The Son – Director of Military Clinical Embryology Institute
    Topic: Application of Genetic and Genomic Technologies in Assisted Reproduction

  • Assoc. Prof. Dr. Tran Van Khoa – Head of Biology-Genetics Department, Military Medical Academy
    Topic: Genetic Testing and Counseling for Fetal Ultrasound Abnormalities

  • Dr. Pham Dinh Minh – R&D Director, GENTIS
    Topic: Development and Application of Bioinformatics and Artificial Intelligence in Screening, Counseling, and Management of Genetic Diseases

  • Dr. Doan Xuan Kien – Director of Reproductive and Andrology Center, Phu Tho Obstetrics and Pediatrics Hospital
    Topic: Implantation Failure: Evidence Update Related to Chronic Endometritis and Genetic Abnormalities

  • Dr. Le Vu Hai Duy – Phuong Dong General Hospital
    Topic: Mutation Spectrum of Congenital Thalassemia in Vietnam and One PGT-M Thalassemia Solution for Couples Carrying Disease Genes to Have Healthy Offspring

  • Specialist Dr. Le Thao Ly – Quang Ninh Obstetrics and Pediatrics Hospital
    Topic: Male Infertility: Main Causes and Stratified Diagnostic Testing for Treatment

Who Should Attend?

  • Obstetricians, reproductive medicine specialists

  • Geneticists, laboratory technicians, biotechnology professionals

  • Representatives from hospitals, IVF centers, clinics

  • Medical researchers and lecturers

  • Medical students interested in assisted reproduction and precision medicine

Reasons Not to Miss This Workshop:

  • Update in-depth knowledge and keep pace with AI and genetic trends

  • Direct interaction with leading experts

  • Expand professional networks and inter-institutional collaboration

  • Opportunities for sharing, exchanging, and learning from clinical practice

The Organizing Committee sincerely invites distinguished delegates to attend and accompany the development of assisted reproductive medicine in Vietnam!

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This is one of the highlight events of 2025, not only marking a milestone in GENTIS’s development but also serving as a valuable opportunity for professionals to update the latest advances in genetics and assisted reproduction—two rapidly evolving scientific fields that play a crucial role in modern medicine.

When Genetic Technology and AI Transform Reproductive Medicine

In recent years, advances in genetics, gene technology, artificial intelligence (AI), and bioinformatics have created significant breakthroughs in assisted reproduction. From pre-implantation diagnosis, embryo genetic analysis, to genetic risk stratification and infertility treatment optimization—these processes are increasingly automated, precise, and personalized thanks to high-tech support.

Recognizing the importance of this, GENTIS—pioneers in genetic analysis in Vietnam—has partnered with HASAR to organize the first workshop in this celebratory series, aiming to share knowledge, update trends, and connect the medical community in reproductive medicine and genetics.

Workshop: “Updating Knowledge on Genetic Applications and AI Trends in Assisted Reproduction”

  • Date & Time: 1:00 PM – 5:00 PM, Saturday, October 11, 2025

  • Location: 4th Floor, Dolce By Wyndham Hanoi Golden Lake Hotel, B7 Giang Vo, Ba Dinh, Hanoi

  • The event is expected to gather hundreds of experts, doctors, researchers, and representatives from medical institutions nationwide for professional exchange.

  • The workshop proudly features leading experts in assisted reproduction, genetics, and precision medicine.

Workshop Chairs:

  • Prof. Dr. Nguyen Dinh Tao – President of Hanoi Assisted Reproduction Association

  • Assoc. Prof. Dr. Tran Duc Phan – President of Vietnam Medical Genetics Association

  • Dr. Nguyen Quang Vinh – Director of GENTIS Testing Center

Key Presenters and Topics:

  • Assoc. Prof. Dr. Trinh The Son – Director of Military Clinical Embryology Institute
    Topic: Application of Genetic and Genomic Technologies in Assisted Reproduction

  • Assoc. Prof. Dr. Tran Van Khoa – Head of Biology-Genetics Department, Military Medical Academy
    Topic: Genetic Testing and Counseling for Fetal Ultrasound Abnormalities

  • Dr. Pham Dinh Minh – R&D Director, GENTIS
    Topic: Development and Application of Bioinformatics and Artificial Intelligence in Screening, Counseling, and Management of Genetic Diseases

  • Dr. Dao Xuan Kien – Director of Reproductive and Andrology Center, Phu Tho Obstetrics and Pediatrics Hospital
    Topic: Implantation Failure: Evidence Update Related to Chronic Endometritis and Genetic Abnormalities

  • Dr. Le Vu Hai Duy – Phuong Dong General Hospital
    Topic: Mutation Spectrum of Congenital Thalassemia in Vietnam and One PGT-M Thalassemia Solution for Couples Carrying Disease Genes to Have Healthy Offspring

  • Specialist Dr. Le Thao Ly – Quang Ninh Obstetrics and Pediatrics Hospital
    Topic: Male Infertility: Main Causes and Stratified Diagnostic Testing for Treatment

Workshop Highlights: The Intersection of Traditional Medicine and Modern Technology

With comprehensive content presented by leading experts, the workshop not only focuses on sharing theoretical knowledge but also offers practical applications, the latest clinical research, and high-tech solutions successfully implemented at many medical centers.

Notably, the integration of artificial intelligence (AI) in screening, counseling, and treatment steps is opening entirely new pathways, shortening diagnosis time, increasing success rates in assisted reproduction, and enhancing personalized healthcare quality.

Founded in 2010, GENTIS is one of the pioneering units in genetic testing in Vietnam. Over 15 years, GENTIS has continuously expanded its system, invested in technology, and collaborated with leading research units domestically and internationally.
With the mission “Enhancing the intellect and health of Vietnamese people,” GENTIS not only provides high-quality testing services but also actively contributes to medical knowledge enhancement, supports healthcare workforce training, and organizes professional events such as this workshop.

GENTIS and HASAR warmly invite doctors, medical experts, scientists, and all interested individuals in assisted reproduction and genetics to attend the workshop.
This is an excellent opportunity to update specialized knowledge, interact with leading experts, and discuss future directions in genetic applications and AI in reproductive medicine.

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  • Time: 9:00 AM – 10:30 AM, Saturday, September 20, 2025
  • Location: 5th Floor Conference Hall, Hanoi Andrology and Infertility Hospital – 431 Tam Trinh, Hoang Mai, Hanoi
  • Register now at: https://forms.gle/9tCcgqZLofXX9Sm97 or scan the QR code on the event promotional image.
  • Seats are limited, so expectant mothers are encouraged to register quickly to not miss this valuable opportunity!

Antenatal Class – A Solid Foundation for a Happy Motherhood Journey

More than just a medical lesson, AF HANOI offers a meaningful experience helping parents to:

  • Understand the changes during pregnancy

  • Know how to care for physical and mental health

  • Prepare mentally for childbirth and newborn care

Featuring Two Leading Obstetrics and Gynecology Experts:

  • Dr. Nguyen Lien Hiep – Experienced obstetrician specializing in safe pregnancy care and delivery

  • Dr. Dam Dinh Tam – Obstetrics and gynecology expert with many years of experience at major healthcare facilities

These doctors will directly share and answer all questions from A to Z that expectant mothers may have during pregnancy, childbirth, and healthy childrearing.

Benefits for Expectant Mothers Participating in the Class

  • Update accurate and easy-to-understand medical knowledge

  • Through presentations by the doctors, mothers will gain insights into:

    • Proper nutrition during pregnancy

    • Signs of labor and safe delivery methods

    • Guidance on newborn care in the first days of life

    • How to reduce anxiety and maintain a positive mindset during pregnancy

  • Personalized Q&A
    This is a chance for expectant mothers and their families to receive direct consultation from doctors on specific concerns. Each pregnancy is unique, and direct communication with experts will greatly increase parents’ confidence.

Building Connections with Fathers

This class is not only for mothers but also encourages expectant fathers to join. Parenthood is a journey for both partners. When fathers understand the changes, challenges, and feelings mothers go through, their companionship and support become easier and more meaningful.

Exciting Gifts Await

No event is complete without special gifts for participating mothers, including prenatal care products, mother and baby supplies, and quality medical services from GENTIS and partners.

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Thalassemia: A Silent Disease with Serious Consequences

Discussing the current situation, Professor Nguyen Dinh Tao (Chairman of the Hanoi Association for Reproductive Support) shared that approximately 13% of Vietnam's population—equivalent to over 14 million people—are carriers of the Thalassemia gene without knowing it. Each year, around 8,000 children are born with the disease in Vietnam, including 2,000 severe cases and approximately 800 newborn deaths.

Children with severe Thalassemia are dependent on hospitals, blood transfusions, and lifelong treatment. This not only impacts the child’s quality of life but also places a significant financial and emotional burden on the entire family. The estimated cost of treating a Thalassemia patient over their lifetime can reach 2 to 3 billion VND—a substantial amount for most families in Vietnam.

Early Prevention – The Key to a Healthy Generation

According to Dr. Bui Thi Phuong Hoa (Head of the Department of Scientific Research and Training – Hanoi Hospital of Andrology and Infertility), Thalassemia is no longer something to fear if detected and prevented early. With significant progress in genetic medicine, Vietnam now meets international standards in gene screening and testing. Several national programs have been implemented to screen for this condition, especially targeting individuals preparing for marriage and women in early pregnancy.

A simple complete blood count (CBC) test can help detect risk factors through indicators such as MCV and MCH. If these values are low, patients will be recommended for more advanced genetic tests, including PCR, Sanger, or, notably, next-generation sequencing (NGS)—a cutting-edge method currently applied effectively at GENTIS. As a pioneer in the field of genetic testing in Vietnam, GENTIS uses NGS to minimize missed mutations and deliver high accuracy and safety for patients.

Comprehensive Reproductive Solutions for Carrier Couples

If both partners carry the Thalassemia gene, there is a 25% chance that their child will inherit the disease. However, experts advise that couples proactively seek modern medical solutions. One of the most effective methods today is in vitro fertilization (IVF) combined with PGT-M embryo genetic testing, a service currently offered by GENTIS. This approach allows doctors to select healthy embryos free from the Thalassemia gene to be implanted into the mother’s uterus, ensuring the birth of a healthy baby.

In Vietnam, GENTIS leads the way in implementing PGT-M embryo genetic testing. According to Dr. Pham Dinh Minh (R&D Director at GENTIS), with nearly 2,000 IVF cycles and over 3,000 embryos tested for Thalassemia, GENTIS has helped hundreds of families realize their dream of having children without genetic disorders. A major advancement now applied by GENTIS is the One PGT-M solution. This modern technique allows for simultaneous detection of Thalassemia mutations and chromosomal abnormalities (PGT-A/SR) using a single embryo biopsy sample. The method reduces time, optimizes costs, and increases the success rate of treatment.

For families not yet ready for IVF, prenatal diagnostic testing can still be performed to detect genetic abnormalities early and plan appropriate pregnancy care—helping to protect the health of both mother and baby.

Proactive genetic testing and screening should ideally be performed before marriage or early in pregnancy. If a blood test reveals low MCH or MCV levels, even in the absence of family medical history, further genetic testing is strongly recommended. Even when one partner tests negative, it is still essential to test the other partner to ensure a clear genetic profile.

GENTIS – Supporting Families on the Journey to Healthy Children

With a mission to enhance both the physical and mental health of the Vietnamese people, GENTIS continuously innovates and expands its specialized genetic testing services tailored to Vietnamese genetic characteristics. Currently, GENTIS offers two standard Thalassemia screening packages:

  • The Basic Package, covering 5 common Alpha and 16 common Beta mutations.

  • The Comprehensive One PGT-M Package, detecting 8 additional Alpha and over 800 Beta mutations—providing a deeper and more thorough gene analysis.

In addition, GENTIS offers advanced genetic counseling services, accompanying clients from initial testing through fertility consultations to embryo selection and transfer. With a team of leading experts and state-of-the-art laboratories, GENTIS has become a trusted destination for thousands of Vietnamese families on their journey to securing a healthy future for the next generation.

Thalassemia can be entirely prevented if detected and addressed in time. With the support of advanced testing technologies and dedicated units like GENTIS, every family can confidently look forward to welcoming a healthy baby—free from genetic disease.

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As part of the conference, GENTIS was honored to accompany two notable presentations by Dr. Nguyen Van Thong, MD (Head of the Department of Medical Genetics, Hung Vuong Hospital), and Dr. Nguyen Huu Trung, MD, PhD (Head of the Department of Obstetrics and Gynecology, University Medical Center HCMC). These presentations demonstrated GENTIS’s pioneering role in the research and development of applied genetic testing in Vietnam.

PGT-UPGRADE Test: Detecting Embryos with Balanced Translocations

Dr. Nguyen Van Thong presented on the topic: “PGT UPGRADE Testing: Detecting Embryos with Balanced Translocations.” His report focused on a challenge frequently encountered by couples undergoing infertility treatment or those with recurrent miscarriages—the presence of balanced translocations in the genome of one partner.

Balanced translocations are genetic abnormalities in which DNA segments are exchanged between non-homologous chromosomes, without any gain or loss of genetic material at the breakpoints. Carriers of balanced translocations often show no symptoms, but are at high risk of producing embryos with chromosomal abnormalities or non-viable embryos. This can result in miscarriage, stillbirth, or the birth of a child with serious genetic conditions. Therefore, detecting and screening embryos carrying balanced translocations is a crucial step in assisted reproductive treatment.

To address this issue, GENTIS has successfully developed the PGT-UPGRADE test, marking a new advancement in preimplantation genetic diagnosis. This technique allows for the identification of embryos carrying the same balanced translocations as the parent, thereby eliminating the risk of passing on reproductive issues to the next generation. As a result, doctors can select healthy embryos with no genetic risks, increasing implantation rates and offering couples a safer pregnancy journey. This is particularly significant for cases with a history of recurrent miscarriage, unexplained fetal loss, or repeated IVF failure.

With high accuracy and an optimized workflow, PGT-UPGRADE not only brings clinical benefits but also helps save time, reduce costs, and ease emotional burdens for patients. This is a major step by GENTIS in transferring advanced technologies into clinical practice, contributing to the sustainable development of reproductive support in Vietnam.

From Expanded Carrier Screening (ECS) to PGT-M: Preventing Rare Genetic Diseases

Alongside this, the presentation by Dr. Nguyen Huu Trung titled “From Expanded Carrier Screening (ECS) to PGT-M – A Strategy to Prevent Rare Genetic Diseases in Vietnam” offered a broader perspective on controlling inherited disorders at their root.

In the context of rising numbers of monogenic diseases and the high cost of treatment, early identification of genetic risks and proactive intervention before pregnancy has become an urgent necessity in modern medicine.

According to Dr. Trung, Expanded Carrier Screening (ECS) can screen for hundreds of genetic disorders in both men and women, helping identify couples who are carriers of the same recessive genetic mutation. If both partners carry the same disease-causing gene, their children have up to a 25% chance of being affected. In such cases, the optimal solution is to use in vitro fertilization (IVF) combined with PGT-M (Preimplantation Genetic Testing for Monogenic disorders) to screen and select embryos free of the disease-causing genes. This represents a shift from “risk detection” to “proactive prevention”—a strategic direction in preventing rare genetic diseases.

GENTIS is one of the pioneers in deploying and optimizing PGT-M testing panels in Vietnam. With a system that includes more than 100 monogenic diseases—covering both common and rare conditions such as Thalassemia, cystic fibrosis, spinal muscular atrophy (SMA), metabolic disorders, Rett syndrome, and more—GENTIS ensures not only broad test coverage but also high accuracy and rapid turnaround times.

This is made possible through the development of a standardized gene database, a synchronized lab system, and a team of highly trained professionals. In addition, GENTIS places strong emphasis on pre- and post-test genetic counseling, helping patients fully understand their results and make informed decisions based on their family circumstances and reproductive goals.

Genetic Testing – A Practical Tool in Modern Clinical Practice

Both presentations shared an important common message: genetic testing is no longer a distant tool reserved for research or major medical centers, but is increasingly becoming an essential part of modern clinical practice. Thanks to the collaboration between leading experts and applied research units like GENTIS, complex genetic medicine techniques are now more accessible, sustainable, and effective for patients than ever before.

GENTIS's presence at the 10th Can Tho Obstetrics and Gynecology Conference was not merely that of a sponsor, but a clear demonstration of its long-term commitment to improving reproductive healthcare quality in Vietnam. Looking forward, GENTIS aims to continue developing modern genetic solutions, aligned with the mission of “early diagnosis – proactive prevention – healthy babies,” and will continue to work hand-in-hand with the medical community to build a better future for the next generations.

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GENTIS is proud to accompany this year’s conference, carrying the mission of improving public health from the genetic foundation, and introducing advanced genetic testing solutions in the field of assisted reproduction.

A Scientific Forum Connecting Obstetrics and Gynecology Experts

The Can Tho Obstetrics and Gynecology Conference is one of the major events in the Mekong Delta region in 2025, providing an excellent opportunity for physicians, researchers, and medical staff to update their knowledge in obstetrics, gynecology, assisted reproduction, and neonatal care.

The conference will feature numerous high-value scientific presentations, focusing on urgent and relevant topics such as:

  • Updates on diagnostic and treatment protocols for obstetric and gynecological diseases

  • Modern assisted reproductive technologies

  • The application of new technologies in prenatal and neonatal care

  • Genetic research in reproductive medicine

Importantly, the event serves as a platform for experts to share real-world experience, engage in academic exchange, and strengthen collaboration between central and local hospitals, as well as biomedical research units across the country.

GENTIS – Supporting Professional Development and Leading Innovation in Genetic Medicine

As a sponsor, GENTIS brings to the conference an impressive booth, showcasing advanced genetic testing solutions tailored for assisted reproduction – a field that is gaining increasing importance in modern medicine. Some of the key services introduced by GENTIS include:

  • PGT NEXT: Detection of aneuploidy/monosomy

  • PGT UPGRADE: Identification of embryos with balanced translocations

  • PGT-M for 100+ rare diseases: Screening for over 100 monogenic inherited disorders

  • PGT-MAX 1: High-resolution genetic analysis technology

  • Thrombophilia: Screening for blood clotting mutation risks

  • Karyotype: Comprehensive chromosomal analysis

  • Advanced male fertility tests: Assessing male reproductive health (e.g., AZF, CFTR, sperm DNA fragmentation)

With internationally accredited laboratories (CAP, ISO 15189:2022, ISO 27001:2022, ISO 9001:2015), GENTIS continually invests in cutting-edge technology, analytical software, and expert personnel to ensure accurate, fast, and reliable test results.

A Meaningful Experience for Delegates

At this year’s conference, GENTIS not only showcases technical solutions but also creates an open, interactive space at its exhibition booth on August 22, 2025, offering a memorable and meaningful experience for all attendees. At the GENTIS booth, visitors will have the opportunity to:

  • Receive direct consultations from experienced specialists on genetic testing services

  • Learn about how genetic testing is integrated into assisted reproduction workflows to improve IVF success rates

  • Participate in fun mini-games and win exciting gifts

This is also a valuable opportunity for GENTIS to connect with doctors and listen to real-world challenges, helping refine services and develop more specialized tests tailored to the needs of different patient groups.

Over the years, GENTIS has collaborated with hundreds of medical facilities and clinics across Vietnam, contributing to the early screening and treatment of genetic diseases, supporting fertility treatments, improving population health, and bringing hope to thousands of families.

Reaffirming the Bridge Between Genetic Technology and Clinical Medicine

The Can Tho Obstetrics and Gynecology Conference 2025 is not just a platform for GENTIS to showcase its solutions—it is also a chance to reaffirm its role as a bridge between advanced genetic technology and clinical practice, providing doctors with more effective tools for diagnosis and treatment.

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With more than 50 scientific presentations delivered, VAGO 2025 served as an important scientific forum to update new advancements in the diagnosis, treatment, and reproductive healthcare fields. Key topics discussed at this year's conference included obstetrics, gynecology, gynecologic oncology, assisted reproduction, infertility treatment, and advanced techniques in reproductive medicine.

At the conference, GENTIS was honored to collaborate and provide data for the oral presentation by MSc. Dr. Le Thi Phuong Lan (Vinmec Times City International Hospital), titled: “New Perspectives on Selecting Mosaic Embryos for Transfer.” This was one of the key topics at the conference, attracting significant attention from experts in the field of assisted reproduction. The presentation was pioneering, offering updated perspectives on the approach to and handling of mosaic embryos—a subject previously surrounded by much controversy in reproductive medicine.

Mosaic Embryos – From Prejudice to New Opportunities in Embryo Transfer

According to MSc. Dr. Le Thi Phuong Lan, mosaic embryos refer to embryos containing two or more chromosomally distinct cell lines. Traditionally, these embryos were considered "unqualified" for uterine transfer due to the risk of implantation failure, miscarriage, or fetal abnormalities.

The earliest studies on mosaic embryos date back to 1993 (Delhanty – Day 3 embryos) and 1998 (Evisikov – Day 5 embryos). Statistics show the rate of mosaicism in Day 5 embryos ranges from 2–13%, compared to 2.1% in chorionic villus cells and only 0.2% in newborns.

The detection rate of mosaic embryos heavily depends on the diagnostic method used:

  • FISH: screens 5–8 chromosome pairs

  • a-CGH, a-SNP, and NGS: can screen all 23 pairs, with NGS (Next Generation Sequencing) being the most commonly used technique today

Mosaicism may lead to serious consequences such as implantation failure, spontaneous miscarriage, or abnormal fetal development. However, recent insights are gradually changing perspectives on the selection and use of mosaic embryos in embryo transfer.

Factors Influencing the Rate of Embryo Mosaicism

According to Dr. Phuong Lan, there are two main groups of factors influencing mosaicism rates:

  1. Unavoidable factors:
  • Patient-related conditions, notably severe sperm abnormalities (SOAT).

  • Interestingly, female age is not associated with mosaicism—this has been confirmed by recent studies (Viotti, 2021; Girardi, 2020; ASRM, 2023).

  1. Avoidable and improvable factors:
  • Ovarian stimulation protocols.

  • IVF lab techniques: conventional IVF tends to result in higher mosaicism rates than ICSI.

  • Biopsy techniques (flick vs. laser), culture conditions, and embryologist expertise also play crucial roles.

According to current standards, acceptable mosaicism rates should be below 13% (Elkinmuzo, 2024).

In addition, the quality of the genetic lab is a critical factor. Diagnostic methods, technologies, and genetic data analysis software must meet high accuracy standards to deliver reliable results.

Real-World Study Opens New Pathways

Dr. Phuong Lan’s oral presentation highlighted a large-scale practical study conducted in collaboration between Vinmec International Hospital, GENTIS, and IRMET (Italy), led by Assoc. Prof. Francesca Spinella and colleagues. Conducted on 3,094 cases, this is one of the largest known studies on embryo mosaicism to date.

Key findings of the study include:

  • Mosaic embryos can be transferred safely if the mosaicism rate is under 50%.

  • The type of mosaicism (segmental, one chromosome, two chromosomes, or complex) also affects the decision to transfer.

  • New selection criteria help utilize mosaic embryos that were previously discarded.

Dr. Lan shared: “Previously, mosaic embryos were thought to be abnormal and thus were not transferred. However, in reality, mosaic embryos have the potential to self-correct and can be transferred if they meet specific selection criteria.

Particularly, two key conditions must be met:

  1. A high-quality IVF lab with standard equipment, skilled personnel, and techniques that keep actual mosaicism rates below 13%.

  2. A genetic diagnostic center using modern technology like NGS, accurate data interpretation software, and the ability to make clinically sound decisions.”

This marks a significant advance in reproductive clinical practice, opening new opportunities for couples who do not have euploid embryos available for transfer.

GENTIS – A Pioneer in Genetic Analysis for Assisted Reproduction

As a trailblazer in the field of genetic testing, GENTIS constantly innovates and invests in advanced technologies to best serve the reproductive support needs in Vietnam.

GENTIS is one of the first institutions to implement PGT (Preimplantation Genetic Testing) in Vietnam and has achieved several prestigious international accreditations, including:

  • CAP (College of American Pathologists)

  • ISO 15189:2022 – Quality management for medical laboratories

  • ISO 27001:2022 – Information security management

  • ISO 9001:2015 – General quality management

With a team of experienced experts, internationally accredited laboratories, and cutting-edge technology, GENTIS continues to play a vital role in improving infertility treatment outcomes, helping thousands of families welcome healthy babies.

Reaffirming the Role in Research and Clinical Application

GENTIS's involvement in this scientific research not only demonstrates its technological and professional capabilities but also reflects its commitment to accompanying the medical community in finding breakthrough solutions to improve infertility treatment in Vietnam.

The genetic data and analysis provided by GENTIS significantly supported Dr. Phuong Lan's study and reaffirmed GENTIS's central role in bridging research and real-world clinical application.

Once again, GENTIS would like to congratulate the outstanding success of VAGO 2025 and sincerely thank the organizers for creating such a meaningful professional forum, contributing to the advancement of obstetrics and gynecology in Vietnam.

[content_more] => [meta_title] => GENTIS Participates in Research on Mosaic Embryo Transfer at the VAGO 2025 National Obstetrics and G [meta_description] => On August 16, 2025, the National Obstetrics and Gynecology Conference (VAGO 2025) was solemnly held at the Sheraton Hotel, Vinhomes Imperia Urban Area, Hai Phong City. [meta_keyword] => GENTIS,PGT,MOSAIC [thumbnail_alt] => [post_id] => 1347 [category_id] => 4 ) )

Reunion after 31 Years: GENTIS proudly accompanies Arthur Chareire and his biological mother

One afternoon in September, at the GENTIS testing center, the atmosphere suddenly became warmly emotional. It was the moment when Arthur Chareire, a young man with French nationality, was reunited with his biological mother – Mrs. Nguyễn Thị Hợi – after 31 years apart. What seemed like a story straight out of a movie happened in real life, stirring deep emotions among those present.

Workshop program: "Updating knowledge on genetic applications and AI trends in assisted reproduction"

The workshop titled "Updating Knowledge on Genetic Applications and AI Trends in Assisted Reproduction" will take place from 1:00 PM to 5:00 PM on Saturday, October 11, 2025, at the 4th Floor, Dolce By Wyndham Hanoi Golden Lake Hotel, B7 Giang Vo, Ba Dinh, Hanoi.

GENTIS celebrates 15 years of development: launching a special workshop series with HASAR

On the occasion of its 15th anniversary, Gentis Genetic Analysis Services Joint Stock Company (GENTIS), in collaboration with the Hanoi Assisted Reproduction Association (HASAR), officially kicks off a special series of events with the inaugural workshop titled: “Updating Knowledge on Genetic Applications and AI Trends in Assisted Reproduction.”

GENTIS partners with Hanoi Andrology and Infertility Hospital to organize AF HANOI Antenatal class

The journey to motherhood is one of the most sacred and memorable experiences in every woman’s life. However, it is also a challenging path filled with countless questions, worries, and mixed emotions. With the desire to accompany, share, and support expectant mothers during this special period, GENTIS has collaborated with Hanoi Andrology and Infertility Hospital to organize the AF HANOI Antenatal Class, providing parents with comprehensive knowledge, skills, and preparation to warmly welcome their beloved baby.

Proactive Thalassemia Screening – A Solution to Help Carrier Couples Have Healthy Children

Thalassemia is one of the most common and dangerous hereditary blood disorders in Vietnam today. However, thanks to the advancement of modern medicine and the support of pioneering genetic testing institutions like GENTIS, thousands of Vietnamese families have successfully had healthy children—even when one or both parents carry the disease gene.

Breakthroughs in the Application of Genetic Testing in Clinical Practice

The 10th Can Tho Obstetrics and Gynecology Conference, held on August 22, 2025, welcomed over 1,000 delegates, once again affirming its role as a prestigious scientific forum for the Southern region and the entire obstetrics and gynecology community in Vietnam. With nearly 60 scientific presentations, the conference offered valuable professional insights, ranging from updates in diagnostics and treatment to the growing trend of applying advancements in genetics and precision medicine.

GENTIS Proudly Accompanies the Can Tho Obstetrics and Gynecology Conference 2025

From August 21–22, 2025, the Can Tho Obstetrics and Gynecology Conference 2025 will officially take place at the Van Phat Riverside Conference Center in Can Tho City. This prestigious professional event brings together leading experts, doctors, and healthcare professionals from top hospitals and medical centers across Vietnam.

GENTIS Participates in Research on Mosaic Embryo Transfer at the VAGO 2025 National Obstetrics and Gynecology Conference

On August 16, 2025, the National Obstetrics and Gynecology Conference (VAGO 2025) was solemnly held at the Sheraton Hotel, Vinhomes Imperia Urban Area, Hai Phong City. This prestigious professional event brought together over 1,000 delegates, including professors, PhDs, doctors, scientists, and healthcare professionals working in obstetrics and gynecology from hospitals and medical institutions both in Vietnam and abroad.
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